A recent study has raised concerns about the potential link between alcohol consumption and an increased risk of developing Alzheimer’s disease. While it is well-established that excessive alcohol intake can lead to various health issues such as liver disease, heart disease, and cancer, researchers have now discovered a possible connection between alcohol use disorder (AUD) and Alzheimer’s. The study, published in the eNeuro journal, suggests that heavy drinking could accelerate the onset of Alzheimer’s by inducing similar changes in gene expression patterns within the brain.
According to the senior author of the study, Pietro Paolo Sanna from Scripps Research’s immunology and microbiology department, the research found specific genes and pathways that are dysregulated in both Alzheimer’s disease and alcohol use disorder. This indicates that alcohol may impact molecular mechanisms associated with Alzheimer’s, potentially leading to cognitive decline. The study analysed RNA sequencing data from brain cells of patients at different stages of Alzheimer’s, revealing common alterations in brain gene function between AUD and Alzheimer’s, including increased inflammation and disrupted cell signalling.
While the study sheds light on the potential link between alcohol use disorder and Alzheimer’s disease, the researchers emphasise the need for further investigation with larger patient groups to confirm these findings. The ultimate goal is to develop therapeutic strategies to address cognitive decline in individuals with both conditions. The Alzheimer’s Society advises individuals to be mindful of risk factors associated with Alzheimer’s and suggests limiting alcohol consumption to below 14 units per week to reduce the risk of developing the disease.
It is crucial to note that the study underscores the significance of considering alcohol use disorder as a potential risk factor for Alzheimer’s disease. By revealing common molecular mechanisms affected by both AUD and Alzheimer’s, the research highlights the need for a deeper understanding of how alcohol consumption can impact cognitive health. Future studies investigating the relationship between AUD and Alzheimer’s could provide valuable insights into potential preventive measures and treatments for cognitive decline associated with these conditions.